Health Calculators

Progesterone To Estrogen Ratio Calculator

The calculation of the progesterone/estrogen ratio, also known as Pg/E2 or simply P/E2, is an integral part of female hormone imbalance assessment and success prediction in vitro fertilization (IVF).

Progesterone to Estrogen Ratio Calculator

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Table of contents

Step 1 - Estradiol and Progesterone Unit Conversion
Step 2 - Estimation of the progesterone/estradiol ratio
What does the progesterone-to-estrogen ratio serve?

Step 1 - Estradiol and Progesterone Unit Conversion

Calculating the ratio of progesterone and estrogen is difficult because the hormone concentrations are often presented in different units. Progesterone is usually expressed in ng/mL or in nmol/L (nanomole/liter). Estradiol is represented in pg/mL or in pmol/L. It is necessary to use the same units to be able to contrast the two.
  • Progesterone:
  • 1 ng/mL = 3.180547 nmol/L
  • Estradiol:
  • 1 pg/mL = 3.6713 pmol/L
    To convert ng/mL into pg/mL multiply the value by 1000. Or, divide it by 1000 to convert pg/mL into ng/mL.

    Step 2 - Estimation of the progesterone/estradiol ratio

    The calculation of the P/E2 ratio is easy once you have brought the hormone concentrations to one unit of measurement.
    ratio = progesterone / estradiol

    What does the progesterone-to-estrogen ratio serve?

    It is used to determine hormonal dominance for patients with normal levels of progesterone or estradiol (measured during the luteal phase).
  • Progesterone: P or Pg: 11 - 29, ng/mL, or 35 - 95 nmol/L
  • Estradiol E2: 19 - 160pg/mL, or 70-600 pmol/L
  • In healthy women, the progesterone/estradiol ratio should be between 100 and 500. It should be between 100 and 500 for progesterone domination. If it is lower, it could indicate estrogen domination.
    For successful conception, a specific progesterone/estradiol balance is essential. However, because the estradiol concentration is critical here, this ratio is often inversed. These articles are by Dr. Rehana Rehman, and Dr. Irmhild Grber if you are interested in this topic.
  • The Estradiol Progesterone Ratio on Ovulation Induction Day: A determinant of successful pregnancy outcomes after intra-cytoplasmic Sperm Injection
  • High estradiol/progesterone ratio females were able to achieve clinical pregnancy. This was confirmed by positive bhCG and transvaginal scans showing cardiac activity. These females had a significantly higher number of oocytes and an increased rate of implantation.
    Conclusion: A high estradiol/progesterone ratio on the day of ovulation induction predicts the success of Intra cytoplasmic sperm injection.
  • Serum estradiol/progesterone ratio on the day of embryo transfer may predict reproductive outcome following controlled ovarian hyperstimulation and in vitro fertilization:
  • IVF-ET results in controlled ovarian hyperstimulation, which causes excessive follicular growth and supraphysiologic serum levels of E2 (and P)
    Disclaimer! None of the authors, contributors, administrators, vandals, or anyone else connected with PureCalculators, in any way whatsoever, can be responsible for your use of the information contained in or linked to this article.
    Parmis Kazemi
    Article author
    Parmis Kazemi
    Parmis is a content creator who has a passion for writing and creating new things. She is also highly interested in tech and enjoys learning new things.
    Progesterone To Estrogen Ratio Calculator English
    Published: Tue Jun 14 2022
    In category Health calculators
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